Well, just like with the devices, compatibility with Windows 10. It is also important that each particular program should also be compatible with Windows 10 . Most of the programs and games should not have a problem running on Windows 10. If a popular program does not run optimally, it depends on time untill a patch or an update is available to fix any compatibility issues.
However, there are some prgrams or games, generally from some smaller manufacturers, will not run on Windows 10 but they are the exception.